Agreement of Ultrasound Devices and Software

This study is being conducted to determine how consistent ultrasound measurements of leg muscles are when using different machines, scanning approaches, and ways of analyzing the images. The study will include both younger adults who regularly participate in resistance training (ages 18–35) and older adults who do not (age 70 and older). Ultrasound is commonly used in research settings to measure the size and condition of leg muscles, but it is used less often in everyday healthcare due to factors such as equipment availability, cost, and the time needed to review the images. There is growing interest in whether ultrasound can be used more easily in clinics to assess and monitor leg muscle health. The results of this study will help determine if ultrasound is a reliable, efficient, and practical tool for healthcare providers to use when evaluating patients, guiding treatment, and tracking changes in leg muscles over time.

This research study will involve a single in-person visit lasting about 30-45 minutes. During the visit, you will first have your height and weight measured. Then, you will lie comfortably on your back on a padded exam table. A spot on the front of your thigh (your upper leg muscle) will be identified. A small amount of gel will then be placed on the skin, and images of your muscle will be taken using two different ultrasound devices—a larger, cart-based machine (GE Logiq E) and a smaller handheld device (Butterfly iQ3).

Inclusion Qualifications:

Younger adults (18-35 years of age) with a Body Mass Index between 18.5-34.9 kg/m²
Lower body resistance trained ≥ 2x/week for previous 6 months
Older adults (≥ 70 years of age) with a Body Mass Index between 18.5-34.9 kg/m²
No lower body resistance training experience over the previous 6 months

Exclusion Qualifications:

You may not participate in this research opportunity if any of the following applies to you:

Body Mass Index < 18.5 or ≥ 35.0 kg/m²
Lower body injury within previous 6 months
History of knee, hip, or ankle surgery within the previous year
Use of an assisted device or wheelchair
Lower body exercise within the past 24 hours prior to data collection
Alcohol within the past 24 hours
Current/active cancer
Current/active infection
Allergy to ultrasound gel
Inability to lie down on a table for up to 30 minutes.

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