The Influence of Transcranial Magnetic Stimulation (TMS) Interpulse Interval Duration on Lower Limb Corticospinal Excitability

The Influence of Transcranial Magnetic Stimulation (TMS) Interpulse Interval Duration on Lower Limb Corticospinal Excitability

Our laboratory uses a brain stimulation technique known as transcranial magnetic stimulation, or TMS, to study changes in the nervous system following interventions. However, TMS data can be highly variable, so we are interested in finding ways of improving our methodology. This research is being done to determine if the duration between TMS pulses to the brain (i.e., interpulse interval) impacts TMS outcomes. This study will help UCF researchers improve their testing methods when studying neuromuscular plasticity.

If you agree to participate in this study, you will be required to visit the Neuromuscular Plasticity Laboratory for one visit. We expect your participation to last approximately two hours. Upon arrival to the laboratory, we will ask you to fill out screening questionnaires and a consent form, and conduct a series of test to assess your neuromuscular function as well as muscular strength. It is requested that you wear comfortable, athletic shorts. Researchers will ask that you avoid strenuous exercise, such as heavy strength or endurance training, 48 hours prior to your visit. In addition, you will be asked to avoid caffeine and alcohol for 4 and 24 hours, respectively, prior to your visit.

Inclusion Qualifications:

  • Healthy adult aged 18-30 years, with a body mass index between 18.5-35.0 kg/m2.
  • Willingness to comply with exercise, caffeine, and alcohol requirements.
  • Willingness to perform maximal strength testing and undergo brain stimulation.
  • Have no other major underlying health concerns and circumstances as described in the pre-enrollment health screen administered before enrollment.

Exclusion Qualifications:

You may not participate in this research opportunity if any of the following applies to you:
  • History of major musculoskeletal injury or surgery
  • Neuromuscular disease (e.g., Parkinson’s, MS, ALS)
  • Metabolic disease (e.g., diabetes, thyroid disorder, metabolic syndrome)
  • Trouble using or controlling one’s muscles
  • History of cancer
  • History of stroke
  • History of heart attack
  • History of arthritis
  • Use of an assistive walking device or mobility aid within the previous six months
  • Use of anabolic steroids within the past six months
  • History of convulsions, seizures, or syncope
  • History of concussion, as diagnosed by physician
  • Certain medications (e.g., muscle relaxants, benzodiazepines)
  • Very thick hair or certain hairstyles that would impede the TMS coil from making direct contact with the scalp
  • Allergy to rubbing alcohol
  • Current pregnancy
  • Implant of any kind
  • Allergy to silver
  • Diagnosis of any psychiatric condition
  • Use of hormone therapy within the past six months
  • Non-binary gender identity or gender identity not consistent with biological sex

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UCF IRB#: STUDY00004377
PI: Matt S. Stock, Ph.D.
IRB Expiration June 21, 2023
Please consider subscribing to get notified about future research participation opportunities
Recruitment End Date:
August 8, 2022
UCF Education Complex and Gym
12494 University Blvd
Orlando, FL 32816
Time Commitment:
Number of visits: 1
Expected time per visit: 2 hours
Type: $20 Target gift card
Point of Contact:
Kevan Knowles
Faculty Advisors:
Matt Stock
Associated Units:
Physical Therapy
Exercise Physiology & Rehabilitation Science
Short URL:

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