Jason Groshong, Ph.D., directs research in the Sonne Laboratory here at UCF. The laboratory focuses on mechanisms of neurodegeneration in the context of Parkinson’s disease. Jason has previously conducted investigations in the fields of diabetes and obesity, neurobiology, cancer, and plant sciences. Jason’s doctoral work elucidated the immune components of skeletal muscle insulin resistance and exercise adaptation. He earned B.S. degrees in biology, molecular biology, and medical chemistry. Dr. Groshong has enjoyed over two decades as a scientist and mentor, training domestic and international students in scientific method and lab techniques. Jason also serves as co-Instructor of PHT 6306 Pathology/Pharmacology. In his spare time, Jason is an avid outdoorsman, enjoys computers, playing guitar and reading literature.
- Ph.D., Physiology, University of Kentucky
- American Chemical Society
- Sigma Xi
Parkinson’s disease is a movement disorder caused by progressive loss of dopinergic neurons in the substantia nigra. We have identified putative mechanisms involving trophic and immune components that lead to the loss of dopaminergic neurons. Using the rotenone, a mitochondrial complex I inhibitor, to induce metabolic stress in an animal model of Parkinson’s disease, we intend on identifying targets which may lead to treatments and prognostic tools to reverse and treat neurodegenerative disease in humans. Exercise has been shown to be an effective therapy for Parkinson’s patients. We will be using exercise intervention to explore mechanisms which spare dopinergic neurons in vivo.
- Mechanisms of Disease
- Diabetes and Obesity
- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
- Pain Syndromes